Intestinal pH and Absorption and Deposition of Ca47 in the Rachitic Chick.

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Abstract
The duodenal absorption and tibia deposition of radiocalcium (Ca47) from solutions at acid or neutral pH values were determined in 3 to 4 week old rachitic and vit. D3-treated chicks. In all cases, vit. D had a significant enhancing effect on Ca47 absorption. At low pH values ( 2), the relative deposition of absorbed Ca47 in tibia by the 2 groups was about the same; however, at pH values ranging from 4.5-7.0, the % absorbed Ca47 appearing in the tibia of the rachitic chicks was significantly less than that in the vit. D-treated birds. The time pattern of deposition indicated a decreasing difference between the two groups from 2.5 min. to 30 minutes after Ca47 administration. When the Ca47 was injected intravenously in saline, there were no differences in tibia accumulation by the rachitic and vit. D groups. The reason for these observations is unknown but may be due to the presence of a ligand that depressed Ca47 absorption in the rachitic or enhanced deposition in the vit. D-treated chicks. It was emphasized that caution should be used when skeletal uptake of a bone-seeking radionuclide is used as an index of relative absorption.

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