Descending Release of Acetylcholine from the Locally Distended Guinea Pig Ileum

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Abstract
Effects of local distension of the intestinal wall on release of acetylcholine (ACh) from the adjacent non-distended part were studied with the segment of isolated guinea pig ileum. Local distension of the intestinal wall induced increased release of ACh in the distended part and in its anal side but not in its oral side. Such aboral release of ACh by local distension was abolished by tetrodotoxin or atropine in concentrations which did not block release in the distended part. When hexamethonium was applied exclusively to the distending part, significant increase of ACh release was observed in regions oral to and anal to the distended part. Distension stimuli applied to the myenteric plexus are probably transmitted aborally along the network of the Auerbach''s plexus to the anal direction. Release of ACh from the intestine by nicotine or DMPP [1,1-dimethyl-4-phenylpiperazinium halide] differed from that occurring during local distension in that the release was localized to the part of the intestine to which the drug was applied.