Calcitonin Gene-Related Peptide in Morphologically Well-Defíned Type II Neurons of the Enteric Nervous System in the Porcine Small Intestine

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Abstract
The morphological classification of the different neuronal cell types is generally accepted and expanded by us; nevertheless, immunohistochemically and electrophysiologically the existence of clear-cut categories of enteric neurons is frequently questioned. The immunohistochemical results demonstrated in this study, however, provide the first direct link between a morphological type of enteric neuron and an immunohistochemical staining for a distinct peptide. Evidence demonstrates that calcitonin gene-related peptide occurs in only one morphologically defined type of neuron, viz. in type II neurons, and can therefore be regarded as a ‘marker peptide’ for type II neurons. Hence, the present immunohistochemical findings illustrate the validity of the morphological classification of the enteric neurons.

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