Homotactic and heterotactic interactions in aqueous solutions containing some saccharides. Experimental results and an empirical relationship between saccharide solvation and solute–solute interactions

Abstract
The enthalpies of dilution of binary and ternary aqueous solutions at 25 °C containing the isomeric disaccharides cellobiose, maltose and trehalose have been investigated. The considerable variation in the enthalpic second virial coefficients appears to be related to the tendency the molecules have to hydrogen bond to the solvent, and using the results obtained, in association with literature information for other saccharide-containing systems, it is shown that a reasonable correlation can be obtained between the virial coefficients and hydrogen-bond numbers deduced from model-building studies.

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