COMPARATIVE EFFECTS OF CITROVORUM FACTOR AND CARBOXYPEPTIDASE G1 ON CEREBROSPINAL FLUID METHOTREXATE PHARMACOKINETICS

  • 1 January 1978
    • journal article
    • research article
    • Vol. 62  (10) , 1549-1552
Abstract
A comparison between citrovorum factor (CF) and carboxypeptidase G1 (CPDGg) rescue with respect to CSF-methotrexate (MTX) disappearance was studied in a patient with recurrent medulloblastoma who had a ventriculoperitoneal shunt. CPDG1 rescue resulted in a prolonged CSF-MTX half-life of 16.5-23 h in comparison with CF rescue where the CSF-MTX half-life was 6.5-7.2 h. There was a positive clinical response measured by loss of bone pain, increased physical activity, and almost complete clearing of CSF blast cells. CPDG1 rescue after high-dose MTX may provide more intense and selective treatment for meningeal neoplasms.

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