INTERACTION BETWEEN RADIATION AND ADRIAMYCIN DAMAGE IN MAMMALIAN-CELLS
- 1 January 1977
- journal article
- research article
- Vol. 37 (6) , 1624-1630
Abstract
Interaction between radiation and adriamycin damage reduced the width of the shoulder of the X-ray survival curve. This effect persisted for at least 24 h after adriamycin treatment. Adriamycin did not affect radiosensitivity. The drug did not suppress repair of radiation damage when [Chinese hamster V79-182 lung] cells were treated before 2 dose fractionation or with the drug present between X-ray exposures. Adriamycin is unique in that its major effect on radiation response is to reduce the survival curve shoulder without affecting 2 dose recovery. Adriamycin and radiation produce independent classes of damage that are expressed mutually for killing, with regard to the registration of sublethal radiation damage, but repair of the latter is unaffected by adriamycin.This publication has 7 references indexed in Scilit:
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