HIGHLY STEREOSELECTIVE ALDOL-TYPE REACTION OF CHIRAL TIN(II) ENOLATE. FORMAL TOTAL SYNTHESIS OF (±)-THIENAMYCIN

Abstract
Highly efficient internal chiral induction is achieved in the aldol-type reaction of tin(II) enolate generated from 3-amino-substituted butanoylthiazolidine-2-thione. This reaction is successfully applied to the formal total synthesis of (±)-thienamycin.