SUPPRESSION BY ORALLY‐ADMINISTERED NIFEDIPINE, NISOLDIPINE AND NILUDIPINE OF EARLY, LIFE‐THREATENING VENTRICULAR ARRHYTHMIAS RESULTING FROM ACUTE MYOCARDIAL ISCHAEMIA

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Abstract
The oral administration to rats of the calcium antagonists nifedipine, nisoldipine and niludipine (3 mg/kg, 1 —1.25 h before acute coronary ligation) greatly reduced the duration of ventricular tachycardia and fibrillation (VF) occurring in the first 30min post‐ligation period. The duration of VF was especially reduced (by 74–92%). None of the animals so treated died compared with a 40% mortality in the controls.