Human Chromosome 19 and Related Regions in Mouse: Conservative and Lineage-Specific Evolution

6 July 2001

journal article
research article
Published by American Association for the Advancement of Science (AAAS) in Science

Vol. 293 (5527) , 104-111
https://doi.org/10.1126/science.1060310

Abstract

To illuminate the function and evolutionary history of both genomes, we sequenced mouse DNA related to human chromosome 19. Comparative sequence alignments yielded confirmatory evidence for hypothetical genes and identified exons, regulatory elements, and candidate genes that were missed by other predictive methods. Chromosome-wide comparisons revealed a difference between single-copy HSA19 genes, which are overwhelmingly conserved in mouse, and genes residing in tandem familial clusters, which differ extensively in number, coding capacity, and organization between the two species. Finally, we sequenced breakpoints of all 15 evolutionary rearrangements, providing a view of the forces that drive chromosome evolution in mammals.

Keywords

This publication has 32 references indexed in Scilit:

Homology-Driven Assembly of a Sequence-Ready Mouse BAC Contig Map Spanning Regions Related to the 46-Mb Gene-Rich Euchromatic Segments of Human Chromosome 19
Genomics, 2001
The Sequence of the Human Genome
Science, 2001
Mouse–Human Orthology Relationships in an Olfactory Receptor Gene Cluster
Genomics, 2001
Canine genetics comes of age
Trends in Genetics, 2000
Differential Expansion of the N-Formylpeptide Receptor Gene Cluster in Human and Mouse
Genomics, 1998
Gapped BLAST and PSI-BLAST: a new generation of protein database search programs
Nucleic Acids Research, 1997
An Improved Sequence Assembly Program
Genomics, 1996
The chromosomal distribution of mouse odorant receptor genes.
Proceedings of the National Academy of Sciences, 1996
A novel family of genes encoding putative pheromone receptors in mammals
Cell, 1995
The apolipoprotein(a) gene is regulated by sex hormones and acute–phase inducers in YAC transgenic mice
Nature Genetics, 1995