Stereoselective synthesis of (Rp)-benzylphenyl-[2-(S)-bromomethylpyrrolidine-1-yl]phosphine oxide from (S)-(+)-prolinol by the Michaelis–Arbuzov reaction: application in the synthesis of a chiral hybrid phosphine–phosphine oxide ligand
- 1 January 1989
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Chemical Communications
- No. 12,p. 805-807
- https://doi.org/10.1039/c39890000805
Abstract
The chiral oxazaphospholidine (2) derived from (S)-(+)-prolinol reacts with benzyl bromide in a stereoselective Michaelis–Arbuzov reaction to give (3), an ideal precursor for the synthesis of the chiral hybrid phosphine–phosphine oxide ligand (5).Keywords
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