Plasma Concentration of Secretin and Gastric Secretion following Intraduodenal Calcium Infusion in Man

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Abstract
The previously demonstrated release of immunoreactive plasma secretin following intraduodenal bile infusion was studied to determine whether it could be mediated by the Ca content of the bile. The gastric acid secretion and the serum concentration of gastrin, ionized and total Ca, calcitonin and parathyroid hormone were also measured. A total amount of 93 mg Ca was infused intraduodenally in 8 healthy volunteers during constant gastric aspiration. No effect was seen on the concentration of immunoreactive plasma secretin or serum gastrin levels in peripheral blood. The total serum Ca concentration decreased slightly during the infusion and increased immediately thereafter. Ionized serum Ca increased throughout the experiment, the increase being significant only after the Ca infusion was stopped. No effects were observed on the serum concentrations of calcitonin and parathyroid hormone.