Easyhaler® Multiple Dose Powder Inhaler—Practical and Effective Alternative to the Pressurized MDI

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Abstract
Due to the depletion of ozone layer linked to CFf propellants used in metered-dose inhalers (MDIs), alternative drug delivery systems for inhalation therapy of bronchial asthma is required. Dry powder inhalers have become a remarkable alternative to the MDIs. The research of powder delivery systems has strongly been focused on developing portable, preloaded multiple-dose powder inhalers, from which patients can reliably inhale several drug doses. Recently, a novel multiple-dose powder inhaler (Easyhaler®) has been developed. Easyhaler® is a suitable drug delivery system for various drugs already available or still under development. Optimum patient compliance is achieved by a design similar to the dose delivery system of the conventional MDI. In addition, the construction of the device allows high dose reproducibility and good in vitro and in vivo deposition of inhaled drug particles. Consequently, equal therapeutic efficacy, safety and tolerability with an MDI is documented in clinical trials. Thus the pharmaceutical, biopharmaceutical, and clinical features as well as the similar mode of use would facilitate a smooth transition from the freon based MDIs to the Easyhaler® multiple-dose powder inhaler.