Marathon Run II: Effects on Platelet Aggregation

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Abstract
Platelet count and aggregation were assessed in 9 Finnish amateur runners aged 34 to 48, and one 65-year old taking part in a non-competitive marathon race (42.2 km). After the run the mean value of platelet count showed a very significant rise (p <0.001). The platelets were markedly more sensitive to both ADP and collagen-induced aggregation. A highly significant increase (p <0.001) was noted for both the intensity and velocity of platelet aggregation. The finding of platelet hyperaggregability after prolonged strenuous exercise even in trained subjects is discussed. It is concluded that a thorough medical examination of the haemostatic balance is recommended before a marathon race.