INHIBITION OF ESCHERICHIA COLI BY p-AMINOBENZOIC ACID AND ITS REVERSAL BY p-HYDROXYBENZOIC ACID
Open Access
- 1 September 1951
- journal article
- research article
- Published by Rockefeller University Press in The Journal of Experimental Medicine
- Vol. 94 (3) , 243-254
- https://doi.org/10.1084/jem.94.3.243
Abstract
p-Aminobenzoic acid (PABA) exerts three metabolic effects on E. coli: it acts as a normal vitamin at low concentrations, as a source of another vitamin, p-hydroxybenzoic acid (POB), at moderate concentrations, and as a growth inhibitor at high concentrations (150 to 1600 µg./ml.). The inhibition is competitively reversed by POB in 1/100 the concentration of PABA. The inhibition is also reversed to a limited extent by shikimic acid and compound X, precursors of POB.Keywords
This publication has 13 references indexed in Scilit:
- AROMATIC BIOSYNTHESIS .1. THE ROLE OF SHIKIMIC ACID1951
- p-Hydroxybenzoic Acid: a New Bacterial VitaminNature, 1950
- PANTOTHENATE STUDIES IJournal of Bacteriology, 1950
- THE SULFONAMIDE-REQUIRING MUTANT OF NEUROSPORA: THREONINE-METHIONINE ANTAGONISMJournal of Bacteriology, 1950
- MUTANTS OF ESCHERICHIA COLI REQUIRING METHIONINE OR VITAMIN B 12Journal of Bacteriology, 1950
- The p -Aminobenzoic Acid Requirement of the “Sulfonamide-Requiring” Mutant Strain of NeurosporaProceedings of the National Academy of Sciences, 1948
- The fungistatic properties of p‐aminobenzoic acid and related compounds. Part I. Growth curves obtained with aspergillus niger, penicillium roqueforti and byssochlamys fulvaJournal of the Society of Chemical Industry, 1948
- Inhibition of Mould Growth by p-Aminobenzoic Acid and the n-Butyl EsterNature, 1945
- EFFECT OF ENZYME INHIBITORS AND ACTIVATORS ON THE MULTIPLICATION OF TYPHUS RICKETTSIAEThe Journal of Experimental Medicine, 1944
- Relationships between the Structure and the Bactericidal Properties of Phenols.Chemical Reviews, 1941