Studies of a Recombinant which Inherited the Haemagglutinin from the Human Influenza Virus A/Hong Kong/1/68 (H3N2) and Other Genes from Influenza Virus A/duck/Ukraine/1/63 (H3N8)

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Abstract
A recombinant (R3/3) has been obtained which inherited the gene coding for the hemagglutinin from human influenza virus A/Hong Kong/1/68 (H3N2), and 7 other genes from influenza virus A/duck Ukraine/1/63 (H3N8). The recombinant R3/3 had properites, a ts+ phenotype and a capability of reproducing in chicK embryos, similar to those of the duck influenza virus, but, in contrast to this parent, had lost its ability to reproduce in organ cultures of ducks and chickens as well as in monolayer cultures of chick embryo fibroblasts.