Hemoglobin Shuangfeng (α27(B8) GLb→LYS): A New Unstable Hemoglobin Variant
- 1 January 1981
- journal article
- research article
- Published by Taylor & Francis in Hemoglobin
- Vol. 5 (7-8) , 691-700
- https://doi.org/10.3109/03630268108991837
Abstract
An unstable hemoglobin variant was found in a 24-year-old Chinese of Han origin. It had an electrophoretic mobility slightly faster than that of Hb A2, but could not be separated from it completely by cellulose acetate elec-trophoresis (pH 8.6). Chromatography on a DE-52 column showed that the variant amounted to approximately 13% of the total hemoglobin. Structural analysis showed that the hemoglobin had the structure α27(B8) Glu→Lys. It was named Hemoglobin Shuangfeng. The α27 Glu residue is an invariable residue located near the α1βl contact.Keywords
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