Investigations on the Influence of Oxyphenbutazone on Formation of Galactose-Induced Cataracts in Rats
- 1 January 1971
- journal article
- Published by S. Karger AG in Ophthalmic Research
- Vol. 2 (1) , 60-63
- https://doi.org/10.1159/000264543
Abstract
Testing the ocular side effects of new drugs, it is not sufficient to investigate cataractogenic effects in normal lenses. Some substances not cataractogenic themselves may act as additionalnoxae when combined with other subliminal cataractogenics. The effect of oxyphenbutazone (5% and 10% Tanderil eye ointment) on formation and progress of galactose-induced cataracts was investigated in rats. OPB did not promote or aggravate the experimental opacities. On the contrary, it seemed to cause a slower progression of cataracts.Keywords
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