Amoxapine and amitriptyline
- 1 May 1984
- journal article
- research article
- Published by Springer Nature in Psychopharmacology
- Vol. 83 (2) , 129-133
- https://doi.org/10.1007/bf00429720
Abstract
Speed of onset of antidepressant effect was studied in 20 depressed outpatients assigned double-blind to equipotent doses of amoxapine or amitriptyline. In counterbalanced order, each patient had 2 periods of 3 weeks on active agent interspersed with 2 similar periods of placebo control. On daily and weekly self-ratings, amoxapine was found to reduce symptoms significantly more rapidly than amitriptyline. Psychiatrist-ratings were consonant with selfreports.Keywords
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