Increased Levels of Neuron-Specific Enolase in PC 12 Pheochromocytoma Cells as a Result of Nerve Growth Factor Treatment
- 1 September 1982
- journal article
- research article
- Published by Wiley in Journal of Neurochemistry
- Vol. 37 (3) , 597-600
- https://doi.org/10.1111/j.1471-4159.1982.tb12528.x
Abstract
Treatment of PC 12 pheochromocytoma cells with nerve growth factor (NGF) resulted in increased levels of neuron-specific enolase (NSE). Neither insulin, growth hormone, cytochrome c, nor sodium butyrate increased NSE levels. Epidermal growth factor (EGF) did increase NSE levels, although not to the same extent as NGF. As little as 1 ng/ml NGF induced the maximal increase in NSE. As PC 12 cells increased in density, the NSE levels increased even in untreated cells.Keywords
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