STUDIES IN RHEUMATIC FEVER II. ABSORPTION OF SALICYLATES

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Abstract
To attain the serum salicylate of 20-30 mg. or higher which Coburn recommended in the treatment of rheumatic fever, a daily admn. of 10 g. salicylate in 6 divided doses by mouth was sufficient in all but a very few cases if the medication was actually swallowed. Since salicylate is unpleasant to take and has cerebral effects which induce blunting of sense of responsibility, patients may fail to take the prescribed dose unless carefully supervised. Absorption is rapid and efficient following oral admn., slow and meager following rectal admn. Since the drug is normally absorbed from high in the gastro-intestinal tract, enteric coating of the tablets seems contraindicated. A daily total of 4 g. of NaHCO3 with 10 g. of salicylate did not seem to affect the serum salicylate level. Intraven. admn. is seldom indicated.

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