Optimal sequence alignments
- 1 March 1983
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 80 (5) , 1382-1386
- https://doi.org/10.1073/pnas.80.5.1382
Abstract
Current theory is adequate to the task of finding an optimal alignment between 2 character strings such as nucleic acids. Most algorithms currently in use must fail to find the homologous alignment between a set of codons for the chicken .alpha.- and .beta.-Hb sequence when it is in fact discoverable by a more general treatment of gaps. Fundamental reasons for this are discussed.Keywords
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