Abstract
Symmetrical calcifications in the brain of a 49-year-old male with a history of physical and mental deterioration were studied macroscopically and microscopically, with special attention to the vascular supply. Regional selectivity in cortical boundary zones located between major arterial areas apparently is responsible for the localization of calcifying lesions. Endocrine disturbances and infectious diseases of the nervous system have been related to cases of cerebral calcification and resulting altered capillary permeability may be the factor involved.