THE PENETRATION OF DAPSONE, RIFAMPICIN, ISONIAZID AND PYRAZINAMIDE INTO PERIPHERAL NERVES
Open Access
- 1 September 1975
- journal article
- Published by Wiley in British Journal of Pharmacology
- Vol. 55 (1) , 151-155
- https://doi.org/10.1111/j.1476-5381.1975.tb07623.x
Abstract
1 Dapsone, rifampicin, isoniazid and pyrazinamide were shown to penetrate readily into the sciatic nerves of the dog and sheep. 2 These findings suggest that the continued persistence of viable drug-sensitive leprosy bacilli in the peripheral nerves of patients treated for long periods with either dapsone or rifampicin is not due to inadequate intraneural drug penetration.Keywords
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