ANALYSIS OF THE BLOOD SUGAR RESPONSE OF OBESE-HYPERGLYCEMIC MICE AND NORMAL MICE TO HORMONES: INSULIN, GLUCAGON, AND EPINEPHRINE1

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Abstract
Obese-hyperglycemic mice showed a hypoglycemic response to administered insulin comparable in magnitude to that displayed by their insulinized non-obese controls. However, obese mice were not killed by insulin even when given repeated doses under fasting conditions. Non-obese control animals when treated under similar conditions with insulin were always killed by this hormone. The fed obese-hyperglycemic mice displayed hyperglycemic responses of 79 mg% and 149 mg%, respectively, to the parenteral administration of 25 fig of glucagon or epinephrine. After a 12-hour fast glucagon and epinephrine produced 197 mg% and 249 mg% increases, respectively, in the blood sugar of the obese mice. In contrast glucagon produced a small increase in blood sugar in the fed non-obese controls which was completely abolished by fasting. Epinephrine caused a marked hyperglycemic response in the fed non-obese mice; the hyperglycemia produced by this hormone was significantly decreased under fasting conditions.[long dash].

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