Melanin‐concentrating hormone: A structural and conformational study based on synthesis, biological activity, high‐field nmr, and molecular modeling techniques

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Abstract
A series of Melanin-concentrating hormone (MCH) fragments have been synthesized and their biological activities compared with the parent peptide. The substructural units, 5-14 linear and 5-14 cyclic, have been used as models for MCH— in 1H-nmr conformational studies. Conformational features predicted by molecular dynamics analyses find support in the nmr experiments.