TREATMENT OF MALIGNANT EDEMATOUS EXOPHTHALMOS BY IMPLANTATION OF THE PITUITARY WITH YTTRIUM90: REPORT OF TWO CASES
- 1 May 1959
- journal article
- research article
- Published by The Endocrine Society in Journal of Clinical Endocrinology & Metabolism
- Vol. 19 (5) , 583-589
- https://doi.org/10.1210/jcem-19-5-583
Abstract
Two cases of malignant exophthalmos refractory to the usual medical and roentgenologic therapy were treated by implantation of the pituitary with radioyttrium (Y90). In both cases prompt and marked improvement of the ocular symptomatology occurred, in association with normalization of thyroid function. These results persisted in one case for at least sixteen months after the implantation; the other case was followed for only one month. No adrenocortical deficiency was observed. This effect of implantation of Y90 is interpreted as due to selective radiobiologic inhibition of the hyperactive pituitary cells which produce the thyrotropic hormone.Keywords
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