Biological Factors Involved in Poisoning Rats with Alpha-Naphthyl Thiourea (ANTU).
- 1 November 1946
- journal article
- research article
- Published by Frontiers Media SA in Experimental Biology and Medicine
- Vol. 63 (2) , 364-372
- https://doi.org/10.3181/00379727-63-15603
Abstract
Adult domestic Norway rats were found to accept ANTU when mixed with the stock diet in concs. at least as high as 10%. In all concs. from 0.1% to 10%, inclusive, the ANTU-poisoned food killed 100% of the rats. Lower concs. of ANTU-poisoned food gave a 100% survival. When fed sublethal concs. of ANTU food from 0.05% to 0.005%, inclusive, for 14 days, the rats developed a marked tolerance and refusal; lower concs. failed to produce either. In some rats the tolerance disappeared at the end of 16 days and was almost imperceptible in all of the rats at the end of 30 days. The refusal decreased after 16 days, though in some animals it was definitely present even at the end of 30 days.Keywords
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