Interleukin-1β stimulates fibroblast elastase activity
- 1 June 1991
- journal article
- Published by Oxford University Press (OUP) in British Journal of Dermatology
- Vol. 124 (6) , 538-541
- https://doi.org/10.1111/j.1365-2133.1991.tb04946.x
Abstract
We report the stimulation of elastase activity of human skin fibroblasts by interleukin-1 beta (IL-1). Elastase activity was determined by the hydrolysis of the synthetic substrate succinoyl trialanine paranitroanilide (Suc(Ala3)NA). Recombinant human IL-1 beta induced a concentration-dependent increase in the elastase activity of fibroblasts. The supernatants of keratinocyte cultures that contained IL-1/ETAF showed similar stimulatory activity.Keywords
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