Transient activation of β-catenin signaling in cutaneous keratinocytes is sufficient to trigger the active growth phase of the hair cycle in mice
Top Cited Papers
Open Access
- 15 May 2003
- journal article
- Published by Cold Spring Harbor Laboratory in Genes & Development
- Vol. 17 (10) , 1219-1224
- https://doi.org/10.1101/gad.1076103
Abstract
Wnts have key roles in many developmental processes, including hair follicle growth and differentiation. Stabilization of β-catenin is essential in the canonical Wnt signaling pathway. We developed transgenic mice expressing a regulated form of β-catenin in the skin. Chronic activation of β-catenin in resting (telogen) hair follicles resulted in changes consistent with induction of an exaggerated, aberrant growth phase (anagen). Transient activation of β-catenin produced a normal anagen. Our data lend strong support to the notion that a Wnt/β-catenin signal operating on hair follicle precursor cells serves as a crucial proximal signal for the telogen–anagen transition.Keywords
This publication has 21 references indexed in Scilit:
- WNT Signals Are Required for the Initiation of Hair Follicle DevelopmentDevelopmental Cell, 2002
- ITF-2, a downstream target of the Wnt/TCF pathway, is activated in human cancers with β-catenin defects and promotes neoplastic transformationCancer Cell, 2002
- Molecular Mechanisms Regulating Hair Follicle DevelopmentJournal of Investigative Dermatology, 2002
- A Comprehensive Guide for the Accurate Classification of Murine Hair Follicles in Distinct Hair Cycle StagesJournal of Investigative Dermatology, 2001
- Tcf3 and Lef1 regulate lineage differentiation of multipotent stem cells in skinGenes & Development, 2001
- β-Catenin Controls Hair Follicle Morphogenesis and Stem Cell Differentiation in the SkinCell, 2001
- Wnt Signaling in Oncogenesis and Embryogenesis--a Look Outside the NucleusScience, 2000
- De Novo Hair Follicle Morphogenesis and Hair Tumors in Mice Expressing a Truncated β-Catenin in SkinCell, 1998
- Development of several organs that require inductive epithelial-mesenchymal interactions is impaired in LEF-1-deficient mice.Genes & Development, 1994
- Sequences 5′ of the bovine keratin 5 gene direct tissue- and cell-type-specific expression of a lacZ gene in the adult and during developmentDifferentiation, 1994