INFLUENCE OF URAPIDIL ON INTRACRANIAL PRESSURE AND INTRACRANIAL COMPLIANCE IN DOGS

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Abstract
During induced hypotension with urapidil, measurements of intracranial pressure and of the ventricular volume-pressure response (intracranial compliance) were obtained in dogs with and without intracranial hypertension. A bolus of urapidil 50 mg plus an infusion of urapidil 8.2±1.2 mg min−1 decreased mean arterial pressure by 22±10% from control in group I (without intracranial hypertension) and by 24±8% in group II (with intracranial hypertension). In both groups there was no change in intracranial pressure or in intracranial compliance after the administration of urapidil.