A preliminary study on the therapeutic effect of a calcium antagonist(diltiazem) on primary congestive cardiomyopathy. A clinical survey of 15 cases.

1 January 1988

journal article
research article
Published by International Heart Journal (Japanese Heart Journal) in Japanese Heart Journal

Vol. 29 (3) , 325-333
https://doi.org/10.1536/ihj.29.325

Abstract

The clinical effects of diltiazem in 15 patients with congestive cardiomyopathy were observed. Symptoms were controlled in 66% and cardiac enlargement improved in 73.3%. There was a decrease in cardiac silhouette on X-ray in 18.82 .+-. 3.2% (p < 0.01), with an increase of EF(%), CO, CI and a decrease of TPR on two-dimensional (2-D) echocardiogram (p < 0.01). Prior to treatment, the cardiac status of 8 cases was grade III and 7 cases grade IV; after treatment 1 case was grade I, 8 grade II, 5 grade III and 1 grade IV. This improvement might be due to the blockade of calcium channels and the fact that diltiazem has the least negative inotropic effect among the calcium antagonists. The dosage, route of administration, and prevention of side effects are discussed.

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