Insecticidal Benzoylphenyl Ureas: Structure-Activity Relationships as Chitin Synthesis Inhibitors
- 30 June 1978
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 200 (4349) , 1499-1500
- https://doi.org/10.1126/science.200.4349.1499
Abstract
The 1-benzoyl-3-phenylurea insecticide diflubenzuron is a potent inhibitor for the conversion of 14C-labeled glucose to 14C-labeled chitin in isolated abdomens of newly emerged adult milkweed bugs (Oncopeltus fasciatus Dallas). The inhibitory activity of 24 diflubenzuron analogs in this in vitro chitin-synthesizing system is in good agreement with their toxicity to fifth instar nymphs of this species. These insecticides act quickly and directly within the integument to ultimately block the terminal polymerization step in chitin formation.This publication has 19 references indexed in Scilit:
- Benzoylphenyl Ureas—A New Group of Larvicides Interfering with Chitin DepositionPublished by American Chemical Society (ACS) ,1977
- The Development of Agricultural AntibioticsPublished by American Chemical Society (ACS) ,1977
- β-Ecdysone levels in pharate pupae of the stable fly, Stomoxys calcitrans and interaction with the chitin inhibitor diflubenzuronJournal of Insect Physiology, 1977
- An assay system for chitin synthesis in insect tissueLife Sciences, 1976
- Synthesis and insecticidal activity of substituted 1-phenyl-3-benzoylureas and 1-phenyl-3-benzoyl-2-thioureasJournal of Agricultural and Food Chemistry, 1976
- Activities of hormone metabolizing enzymes in house flies treated with some substituted urea growth regulatorsLife Sciences, 1975
- The control of chitin deposition by ecdysterone in larvae of Bombyx moriJournal of Insect Physiology, 1973
- Synthesis and laboratory evaluation of 1-(2,6-disubstituted benzoyl)-3-phenylureas, a new class of insecticides. II. Influence of the acyl moiety on insecticidal activityJournal of Agricultural and Food Chemistry, 1973
- Synthesis and laboratory evaluation of 1-(2,6-disubstituted benzoyl)-3-phenylureas, a new class of insecticides. I. 1-(2,5-Dichlorobenzoyl)-3-phenylureasJournal of Agricultural and Food Chemistry, 1973
- Ecdysone titres in the last larva and adult stages of the milkweed bugJournal of Insect Physiology, 1969