Ursodeoxycholate-induced choleresis in taurine-deprived and taurine-supplemented rats.

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Abstract
The effect of i.v. infused ursodeoxycholate (1.2 .mu.mol/(min .cntdot. 100 g body wt)) was compared in control rats and in taurine supplemented (i.p. administration of a taurine solution) and taurine deprived (oral administration of .beta.-alanine) rats. In the control rats, the bile water output during the 1st h was significantly lower than that of the 2nd h, while the bile salt output was significantly lower in the 2nd h. In .beta.-alanine pretreated rats, the increase in the bile flow in the 1st h was more rapid compared to control rats and the bile flow rate reached a peak earlier. The 1st h and total 2 h bile water outputs were significantly higher in the .beta.-alanine pretreated rats compared to the corresponding bile flow values of the control rats, while the bile salt outputs were significantly lower than respective control values. In taurine supplemented rats, the increase in bile flow in the 2nd h was less than in control rats, while the bile salt excretion rate was the highest among the 3 rat groups. Among these 3 groups, the bile flow and bile salt excretion rate during the 1st h and 2 h total infusion periods were negatively correlated. A significant positive correlation was observed between the bile flow rate for 1 or 2 h and bile salt concentration in the liver examined after a 1 or 2 h bile salt infusion. At least part of the bile is produced not by the excretion of bile salt into the bile canaliculus but by its presence inside the hepatocyte (secretory mechanism).