THE GASTRIC ANTISECRETORY ACTIONS OF PROSTAGLANDIN E2 AND STABLE PROSTACYCLIN ANALOGUES AGAINST DIFFERENT SECRETAGOGUES IN PERFUSED WHOLE‐STOMACHS OF RAT OR MOUSE in vitro

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Abstract
The characteristics of the antisecretory actions of prostaglandin E2 (PGE2) and two stable prostacyclin analogues during different rates of acid stimulation have been evaluated in the lumen‐perfused isolated whole stomach of the rat and mouse. In the rat isolated stomach, histamine induced a dose‐dependent increase in acid output. Preincubation with PGE2 caused a dose‐related and surmountable inhibition. The stable prostacyclin analogues, 6β‐PGI1 and a 16‐phenoxy derivative likewise caused a surmountable inhibition of histamine‐stimulated acid output from rat stomach. PGE2 had inconsistent actions on the acid secretion stimulated by pentagastrin, methacholine or dibutyryl cyclic adenosine 3′,5′‐monophosphate. In the mouse isolated stomach, acid secretion was stimulated by low concentrations of histamine, pentagastrin or methacholine. PGE2 failed to inhibit histamine‐stimulated acid output from mouse stomach, but high concentrations of the potent 16‐phenoxy analogue did show anti‐secretory activity. The results indicate the usefulness of the rat isolated stomach for studying the interaction of prostaglandins with the acid secretory process in mammalian gastric mucosa.

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