Synthetic Studies Toward caphalotaxine: Functionalization of Tertiary N-Acylhemiaminals by Nazarov Cyclization

Publisher Website
Google Scholar
Abstract
Functionalization of bicyclic N-acylhemiaminals, which are readily available by titanium-mediated intramolecular coupling of vinyl-tethered imides, has been achieved by use of the Nazarov cyclization to construct the carbon-carbon bond at the quaternary center. This synthetic strategy allows rapid entry to the key structural elements of cephalotaxine.

This publication has 0 references indexed in Scilit: