Meta-analysis of alpha synuclein/ NACP polymorphism in Parkinson's disease in Japan

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Abstract
α Synuclein is a presynaptic protein highly and broadly expressed in the brain but its normal function is unknown.1 The protein is also termed non-amyloid β component precursor (NACP) because of its localisation in amyloid plaques of Alzheimer's disease.1 However, subsequent studies failed to confirm α synuclein as a component of the amyloid plaque.1 α Synuclein/NACP is now known to be a major component of Lewy bodies in Parkinson's disease (PD).1 Point mutations of the α synuclein gene found in three independent PD families suggest that α synuclein may participate in the aetiology of sporadic PD.1 To address this possibility, several groups reported case-control studies using a dinucleotide repeat polymorphism in the promoter region of the gene.2 The previous Japanese study by Izumi et al 3 found a tendency of a lower frequency of allele 1 in Japanese PD patients …

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