Lysosomal mutations inhibit lipofuscinosis of the spleen in C57BL mice
- 1 July 1985
- journal article
- research article
- Published by Oxford University Press (OUP) in Journal of Heredity
- Vol. 76 (4) , 311-312
- https://doi.org/10.1093/oxfordjournals.jhered.a110101
Abstract
Beige, bg, and reduced pigmentation, rp, are recessive mutations affecting lysosomal function. Homozygosity for beige prevented llpofuscinosis of the spleen in C57BL mice and its incidence was greatly reduced by homozygosilty for rp. Dilute (d) homozygotes, with normal lysosomes, were susceptible to lipofusclnosis even though their melanosomes were more severely affected than those of beige mice.Keywords
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