A High-Coverage Genome Sequence from an Archaic Denisovan Individual
Top Cited Papers
- 12 October 2012
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 338 (6104) , 222-226
- https://doi.org/10.1126/science.1224344
Abstract
Ancient Genomics: The Denisovans were archaic humans closely related to Neandertals, whose populations overlapped with the ancestors of modern-day humans. Using a single-stranded library preparation method, Meyer et al. (p. 222 , published online 30 August) provide a detailed analysis of a high-quality Denisovan genome. The genomic sequence provides evidence for very low rates of heterozygosity in the Denisova, probably not because of recent inbreeding, but instead because of a small population size. The genome sequence also illuminates the relationships between humans and archaics, including Neandertals, and establishes a catalog of genetic changes within the human lineage.This publication has 195 references indexed in Scilit:
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