FOCAL MESANGIAL PROLIFERATIVE GLOMERULONEPHRITIS IN RAT CAUSED BY HABU SNAKE-VENOM - MORPHOLOGIC STUDY

  • 1 January 1977
    • journal article
    • research article
    • Vol. 87  (3) , 511-+
Abstract
A new model of focal mesangial proliferative glomerulonephritis in the rat was produced by i.v. habu snake [Trimeresurus flavoviridis] venom. Glomerulonephritis developed in 70% of rats surviving the first 6 h after venom administration. The earliest ultrastructural change (10 min after venom) was the presence of loose platelet aggregates and free granules in the capillary lumen and mesangium. This was followed by dissolution of the matrix and endothelial damage. Between 4-24 h, a characteristic focal and segmental ballooned lesion of glomerular capillaries developed. In these lesions, from 3 days onwards a segmental mesangial proliferation occurred, which persisted until sacrifice at 21 days.