Automatic control of blood pressures with multiple drug inputs
- 1 May 1985
- journal article
- system analysis-in-bio-control
- Published by Springer Nature in Annals of Biomedical Engineering
- Vol. 13 (3-4) , 217-225
- https://doi.org/10.1007/bf02584240
Abstract
Control of arterial blood pressure has been successfully achieved by infusing a single vasoactive drug. However, in clinical practice, blood pressures are frequently controlled using multiple drug infusions. This paper presents a computer based adaptive control algorithm for simultaneous infusions of both an inotropic agent and a vasoactive agent to maintain the blood pressures at desired levels. We present the dynamics of the system with a bilinear two-input, two-output model. A least-squares parameter estimation algorithm has been employed using an output error method. Results of computer simulations of an electrical analog model of the heart and circulatory system are presented.Keywords
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