Stress-Related Negative Affectivity and Genetically Altered Serotonin Transporter Function
Open Access
- 1 September 2006
- journal article
- research article
- Published by American Medical Association (AMA) in Archives of General Psychiatry
- Vol. 63 (9) , 989-996
- https://doi.org/10.1001/archpsyc.63.9.989
Abstract
It is well known that stressful life events (SLEs) increase risk of depression.1 Because only a small proportion of the exposed individuals2 develop a depressive disorder as a consequence, some individuals may be more sensitive to the depression-inducing effects of SLEs than others.3,4 Factors that have been shown to increase sensitivity to SLEs are the personality trait neuroticism,5-10 childhood adversity,9,11 and indirect measures of genetic risk for depression and anxiety, derived from twin or family studies.12-15Keywords
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