Comparison of Liver Glycogen Synthetase between Streptozotocin-Diabetic and Control Rats

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Abstract
Chronic diabetic rat, induced by streptozotocin, showed high blood glucose but low liver glycogen levels. The diabetic liver had subnormal amounts of glycogen synthetase and its I form when assayed in both 8000 × g supernatant and glycogen pellet suspensions. The pellet suspension of the control liver retained 68% synthetase I activity; the diabetic liver retained only 19.5%. The addition of deproteinized liver extract to the pellet suspension increased the activity of synthetase either in the presence or absence of glucose-6-PO4 for both groups of animals to different degrees. The deproteinized liver extract of the diabetic rat contained little ATP, less glucose-6-PO4, and slightly more inorganic phosphate than that of the control rat. The significance of these observations is discussed.

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