Stereochemical Effects in Mass Spectrometry - Determination of the Optical Purity of Enantiomers by Mass Spectrometry
- 1 May 1997
- journal article
- research article
- Published by Taylor & Francis in Analytical Letters
- Vol. 30 (7) , 1399-1406
- https://doi.org/10.1080/00032719708007225
Abstract
Due to the difference in reactivity of enantiomers with chiral reagents, it was found that in the Fast Atom Bombardment (FAB) mass spectra of enantiomer mixtures of R-α-phenylethylamine and S-α-phenylethylamine with a chiral reagent S-phosphorsaeure-(1,1′-bi-naphthyl-2,2′-diylester) (BNP acid), the relative abundance of the characteristic ion is linearly related to the composition of the mixture. We have, therefore, proposed a possible method for the determination of the optical purity of enantiomers by mass spectrometry.Keywords
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