This descriptive, correlational study investigated the relationship between selected variables and the degree of burnout experienced by nurses with a master's degree in nursing who were functioning in the role of an oncology clinical nursing specialist (OCNS). The selected variables were categorized as personal resources, personal perceptions, and role-related variables. The sample of 185 represents 70% of the population of nurses surveyed. Two questionnaires comprised the research instrument. The dependent variable, the degree of burnout, was measured by the Jones Staff Burnout Scale for Health Professionals (SBS-HP) and the independent variables were measured by the Self-Report Questionnaire designed by the researcher. Descriptive statistics were utilized to describe the characteristics of the nurses in the sample and Pearson correlations, multiple regression analysis, and stepwise regression analysis were utilized to describe the relationships between the variables and the degree of burnout experienced by nurses functioning in the role of an oncology clinical nursing specialist. The findings of this study included: 1) a mean burnout score that was significantly lower than mean burnout scores of other nurse samples tested previously with the SBS-HP; 2) docu- mentation of the developmental stages of burnout proposed by Edelwich (1980)-feelings of apathy and withdrawal were experienced by the oncology clinical nursing specialists experiencing a greater degree of burnout; 3) significantly correlated variables (p <0.01) revealed that a greater degree of burnout was experienced by oncology clinical nursing specialists with the following characteristics: younger with fewer children, receiving inadequate psychological support at work, experiencing a high level of stress at work, experiencing dissatisfaction with their role, experiencing feelings of apathy and withdrawal, and answering no when asked if they would choose their present role if given the opportunity to choose again; and 4) the “best” predictors of burnout as determined by a stepwise regression analysis were dissatisfaction with the role, experiencing a high level of stress at work, feelings of apathy and withdrawal, and receiving inadequate psychological support at work. Further study to identify additional predictor variables is necessary since the variables selected for this study accounted for 51.3% of the variences in the degree of burnout experienced by the oncology clinical nursing specialists.