1H and 13C NMR spectra of 1‐palmitoyl‐2‐oleyl‐sn‐glycero‐3‐phosphorylcholine in CDCl3 solution and in sonicated dispersions in 2H2O

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Abstract
A mixed‐acid monounsaturated lecithin, 1‐palmitoyl‐2‐oleyl‐sn‐glycero‐3‐phosphorylcholine (POL), has been synthesized by phospholipase A2 digestion of 1,2 dipalmitoyl‐sn‐glycero‐3‐phosphorylcholine followed by reacylation of the lysolecithin with oleic anhydride.1H (90 MHz) and 13C (25.2 MHz) NMR spectra of POL in CDCl3 solution and in sonicated dispersions in 2H2O have been obtained, and spin‐lattice relaxation times measured. The relaxation times were characteristic of the type of structure formed and reflect molecular motion within the lecithin molecule in each structure. In both systems the spin‐lattice relaxation times increase along the alkyl chains towards the terminal methyl group, showing a corresponding increase in the chain molecular motion, although there are significant differences in the gradation of the changes.