Histological Changes in the Gonads and Reproductive Behavior of House Flies Following Treatment with Chemosterilants p, p-Bis(1-aziridinyl)-N-methylphosphinic Amide and p, p-Bis (1-aziridinyl)-N-(3-methoxypropyl)phosphinothioic Amide123

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Abstract
Evaluation of p, p-bis (l-aziridinyl)-N-methylphosphinic amide and p, p-bis (l-aziridinyl)-N-(3-methoxypropyl)-phosphinothioic amide for histological effects on gonadal tissue was made by feeding treated diet to adult Musca domestica L. A histological study of gonads showed that both compounds caused a drastic reduction in in spermatocyte cells in the testes of male flies, but aspermia never occurred. Some males treated with phosphinothioic amide showed recovery of spermatocyte cells 14 days after treatment. Primary oöcytes in the ovary were least affected, although vacuolation of the yolk was evident in eggs of females treated with either compound. Atrophy of the ovaries began by the 10th day after treatment. The ovaries did not show recovery when the test was terminated 3 weeks after treatment. Females remained monogamous after mating with treated males thus indicating that these matings were satisfactory to the females. Males treated with either compound showed no difference from untreated males in initiation or duration of copulation.

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