Ceftazidime-hydrolysing CTX-M-15 extended-spectrum beta-lactamase (ESBL) in Poland
Open Access
- 1 September 2002
- journal article
- research article
- Published by Oxford University Press (OUP) in Journal of Antimicrobial Chemotherapy
- Vol. 50 (3) , 393-396
- https://doi.org/10.1093/jac/dkf151
Abstract
The CTX-M-15 extended-spectrum β-lactamase (ESBL) was recently identified in Enterobacteriaceae isolates in India, and demonstrated significant hydrolytic activity against ceftazidime, in contrast to the majority of CTX-M enzymes. CTX-M-15 differs from CTX-M-3, which is one of the most prevalent ESBLs in Poland, by only a single amino acid change (Asp-240→Gly). Three cefotaxime- and ceftazidime-resistant Enterobacteriaceae isolates, recovered during 1998–2000 in two Polish hospitals, were found to produce CTX-M-15. Similar to those from India, the isolates contained the ISEcp1 insertion sequence located upstream of the blaCTX-M-15 gene, which has been recently demonstrated to mobilize 3′-adjacent genes to transfer between DNA replicons. However, its different position with respect to the β-lactamase gene indicated the independent selection of the ESBL gene in the two countries.Keywords
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