Kurasoins A and B, New Protein Farnesyltransferase Inhibitors Produced by Paecilomyces sp. FO-3684. II. Structure Elucidation and Total Synthesis.
- 1 January 1996
- journal article
- Published by Japan Antibiotics Research Association in The Journal of Antibiotics
- Vol. 49 (9) , 886-889
- https://doi.org/10.7164/antibiotics.49.886
Abstract
The structures of new protein farnesyltransferase inhibitors, kurasoins A and B, were elucidated by NMR study. Kurasoins A and B are acyloin compounds having in common a 3-hydroxy-1-phenyl-2-butanone moiety, to which p-hydroxyphenyl and 3-indolyl moieties respectively, are connected at C-4. The structures were confirmed by total synthesis.Keywords
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