Symbiotic Bacteria Direct Expression of an Intestinal Bactericidal Lectin
Top Cited Papers
- 25 August 2006
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 313 (5790) , 1126-1130
- https://doi.org/10.1126/science.1127119
Abstract
The mammalian intestine harbors complex societies of beneficial bacteria that are maintained in the lumen with minimal penetration of mucosal surfaces. Microbial colonization of germ-free mice triggers epithelial expression of RegIIIγ, a secreted C-type lectin. RegIIIγ binds intestinal bacteria but lacks the complement recruitment domains present in other microbe-binding mammalian C-type lectins. We show that RegIIIγ and its human counterpart, HIP/PAP, are directly antimicrobial proteins that bind their bacterial targets via interactions with peptidoglycan carbohydrate. We propose that these proteins represent an evolutionarily primitive form of lectin-mediated innate immunity, and that they reveal intestinal strategies for maintaining symbiotic host-microbial relationships.Keywords
This publication has 30 references indexed in Scilit:
- Diversity of the Human Intestinal Microbial FloraScience, 2005
- A Flow-Cytometric Gram-Staining Technique for Milk-Associated BacteriaApplied and Environmental Microbiology, 2003
- HOWHOST-MICROBIALINTERACTIONSSHAPE THENUTRIENTENVIRONMENT OF THEMAMMALIANINTESTINEAnnual Review of Nutrition, 2002
- Expression of the Regenerating Gene Family in Inflammatory Bowel Disease Mucosa: Reg Iα Upregulation, Processing, and Antiapoptotic ActivityJournal of Investigative Medicine, 2002
- Isolation and Characterization of Human μ-Defensin-3, a Novel Human Inducible Peptide AntibioticJournal of Biological Chemistry, 2001
- Mammalian Peptidoglycan Recognition Protein Binds Peptidoglycan with High Affinity, Is Expressed in Neutrophils, and Inhibits Bacterial GrowthJournal of Biological Chemistry, 2000
- A Primitive T Cell-Independent Mechanism of Intestinal Mucosal IgA Responses to Commensal BacteriaScience, 2000
- Human REG family genes are tandemly ordered in a 95‐kilobase region of chromosome 2p12FEBS Letters, 1995
- Engineering galactose-binding activity into a C-type mannose-binding proteinNature, 1992
- RAG-1-deficient mice have no mature B and T lymphocytesCell, 1992