P-Chirogenic Binaphthyl-Substituted Monophosphines: Synthesis and Use in Enolate Vinylation/Arylation Reactions
- 14 February 2002
- journal article
- letter
- Published by American Chemical Society (ACS) in Organic Letters
- Vol. 4 (6) , 999-1001
- https://doi.org/10.1021/ol025563p
Abstract
New phosphine ligands possessing both axial chirality and a chirogenic phosphorus center were prepared from (R)-2-bromo-2‘-N,N-(dimethylamino)-1,1‘-binaphthyl (1) via a simple Li−halogen exchange protocol. The asymmetric vinylation of a ketone enolate with (R,RP)-2-(tert-butylphenylphosphino)-2‘-N,N-(dimethylamino)-1,1‘-binaphthyl (2a) afforded the coupling product with good enantiomeric excess.Keywords
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